Discoidin Domain Receptor Inhibitor

Discoidin Domain Receptor Inhibitors (20):

Cat. No.	상품명	효과	Purity

HY-13979

DDR1-IN-1	Inhibitor	98.0%
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM).

HY-U00444

7rh	Inhibitor	99.31%
7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC₅₀ of 13.1 nM, and also less potently inhibits DDR2, with an IC₅₀ of 203 nM. 7rh is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15514

Merestinib	Inhibitor	99.99%
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-181754

TPKI-39	Inhibitor
TPKI-39 is a DDR1, DDR2, and FLT1 inhibitor, with a human DDR1 IC₅₀ of 380 nM, human DDR1 K_a of 24 nM, human DDR2 IC₅₀ of 120 nM, human FLT1 IC₅₀ of 65 nM, and human FLT1 K_a of 91 nM.TPKI-39 inhibits DDR1 enzymatic activity and autophosphorylation, DDR2 enzymatic activity, and FLT1 enzymatic activity in cells.TPKI-39 inhibits collagen-induced DDR1 autophosphorylation in cells.

HY-112545

DDR2-IN-1	Inhibitor	99.65%
DDR2-IN-1 is potent DDR2 inhibitor with an IC₅₀ of 26 nM. DDR2-IN-1, compound 129, can be used for osteoarthritis research.

HY-W018931

DDR Inhibitor	Inhibitor	99.43%
DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC₅₀ of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

HY-15514A

Merestinib dihydrochloride	Inhibitor	99.36%
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-100695

DDR-TRK-1	Inhibitor	98.90%
DDR-TRK-1, a chemical probe, is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC₅₀ value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

HY-RS03621

Ddr1 Mouse Pre-designed siRNA Set A	Inhibitor
Ddr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03620

DDR1 Human Pre-designed siRNA Set A	Inhibitor
DDR1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03624

Ddr2 Mouse Pre-designed siRNA Set A	Inhibitor
Ddr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03623

DDR2 Human Pre-designed siRNA Set A	Inhibitor
DDR2 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-167745

DDR1-IN-9	Inhibitor	99.64%
DDR1-IN-9 is a selective inhibitor of DDR1 with significant kinase activity suppression, exhibiting a Kd value of 4.7 nM and an IC50 value of 9.4 nM. DDR1-IN-9 demonstrates reduced potency against a diverse panel of 400 nonmutated kinases, indicating its specificity. Additionally, DDR1-IN-9 shows favorable pharmacokinetic properties and potential therapeutic effects in a model of pulmonary fibrosis.

HY-169741

DDR1-IN-10	Inhibitor
DDR1-IN-10 (compound 7q) is a DDR1 inhibitor. DDR1-IN-10 can be used in the study of pancreatic cancer, non-small cell lung cancer, and gastric carcinoma.

HY-174088

CDK4/6/BRD4-IN-2	Inhibitor
CDK4/6/BRD4-IN-2 (Compound PJ2) is a dual inhibitor of CDK4/6 and BRD4 with IC₅₀ values for CDK4, CDK6, BRD4 (BD1), and BRD4 (BD2) of 168.75, 292.45, 23.17, and 3.12 nM respectively. CDK4/6/BRD4-IN-2 has a strong inhibitory effect on non-small cell lung cancer (NSCLC) cell lines. CDK4/6/BRD4-IN-2 induces cell cycle arrest, senescence and apoptosis through ROS-mediated DNA damage. CDK4/6/BRD4-IN-2 can also effectively inhibit the migration and invasion of NCI-H358 cells. CDK4/6-IN-2 can be used for the study of KRAS-mutated NSCLC.

HY-P990400

Anti-DDR1/CD167a Antibody	Inhibitor	99.13%
Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-172797

DDR Inhibitor 2	Inhibitor
DDR Inhibitor 2 (compound 5a) is a discoidin domain receptor (DDR) inhibitor with an IC₅₀ of 0.125 μM. DDR Inhibitor 2 can be used for study of fibrotic diseases.

HY-160689

GW694590A	Inhibitor
GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting DDR2, KIT and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene.

HY-14979

ML786	Inhibitor
ML786 is a potent and orally bioavailable Raf inhibitor, with IC₅₀s of 2.1, 4.2, and 2.5 nM for ^V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC₅₀=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 can be used for the research of cancers.

HY-W778154

O,O-Dimethyl dithiophosphate-¹³C₂ ammonium	Inhibitor
O,O-Dimethyl dithiophosphate-¹³C₂ ammonium is the ¹³C labeled isotope of O,O-Dimethyl dithiophosphate ammonium.

Name
이메일 *

	Sorry, but the email address you supplied was invalid.